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學校獲批2019年度湖北省國際科技合作基地立項建設

近日,湖北省科技廳發布2019年度湖北省國際科技合作基地立項建設的通知,我校生科學院申報的“醫學生物國際科技合作基地”獲批立項建設。該項目旨在通過跟美國奧爾巴尼醫學院合作開展基因敲出獲得模型的小鼠研究,為呼吸系統疾病的治療與預防尋找新的方法。

該項目牽頭人為生科學院醫學生物研究所劉慶華教授。劉教授所在團隊近10年來專注于人類呼吸系統疾病,尤其是哮喘的發病機制研究。本項目在國際科技合作日益全面深入的大背景下,同美國紐約奧爾巴尼醫學院汪永孝教授合作開展基因敲除哮喘小鼠、老年慢性支氣管炎小鼠模型研究,在基因敲除技術CC9的助力下,成功制備了多個基因敲除小鼠品系,為闡明呼吸系統疾病特別是哮喘的發病機制并提供有效的解決途徑和技術支持。該項目最大特色在于,立足民族地區尤其是武陵山區豐富的生物資源,與學院藥用植物和南方少數民族地區生物資源保護與利用工程中心等多個團隊協同創新,在大量的中草藥類植物資源調查及成分分析基礎上,提取以苦物質類為主的有效成分,用于緩解哮喘病典型癥狀氣道高反應作用的研究。該項目的實施將建立新的有效的呼吸系統疾病模式動物,為呼吸系統疾病的預防和治療提供幫助,同時還將加快我國中藥資源特別是武陵山區植物資源的進一步開發利用,發掘我國特色植物資源的的藥用價值。

國際科技合作基地建設屬于國家“十三五”國際科技合作重點建設領域,是加強湖北省國際科技合作基地建設,打造開放創新品牌的重要措施。該基地建設是學校實施標準動物房等科學研究基礎設施建設以來的重要成果之一。

(編輯:陳鵬冰  來源:生科學院)

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